Botox vs Xeomin: Understanding the Differences Between Two Popular Anti-Wrinkle Treatments

“Understanding the differences can help you choose the best option for your needs or as a practitioner” - JC

When it comes to smoothing fine lines and wrinkles, Botox and Xeomin are two well-known treatments that often come up in conversation. While both are highly effective at relaxing wrinkles and delivering a rejuvenated appearance, they have distinct differences that make each product unique. Understanding these differences can help you choose the best option for your needs or provide valuable insight as a practitioner.

Let’s explore what sets Botox and Xeomin apart, from their formulation to their handling and branding.

1. The Formulation: Purity vs. Added Proteins

One of the most notable differences between Botox and Xeomin lies in their formulations:

• Botox: This product, produced by Allergan, contains botulinum toxin type A along with accessory proteins. These proteins act as a protective complex around the active ingredient. While they don’t impact efficacy, some believe they may influence the body’s immune response over time, potentially making treatments less effective with prolonged use.

• Xeomin: Known as the "pure" toxin, Xeomin by Merz Aesthetics contains botulinum toxin type A without the additional accessory proteins. This purified formulation reduces the risk of antibody formation, which could otherwise lessen treatment effectiveness in the long term.

2. The Cold Chain Requirement: Botox’s Sensitivity

Storage and handling are key considerations for aesthetic practitioners, and Botox and Xeomin differ significantly here:

• Botox: Botox must remain refrigerated to preserve its potency. This “cold chain” requirement ensures that the product retains its efficacy from manufacturing to injection. Improper storage or exposure to heat can degrade Botox, making it less effective.

• Xeomin: Unlike Botox, Xeomin does not require refrigeration before reconstitution. Its unique formulation gives it greater stability during storage, making it a convenient option for clinics and practitioners, particularly in remote locations or when managing large inventories.

3. Branding and Recognition: A Household Name vs. the Underdog

Both Botox and Xeomin are recognised globally, but their branding has evolved differently:

• Botox: Botox is arguably the most well-known name in the world of anti-wrinkle treatments. In fact, its brand name has become synonymous with botulinum toxin treatments in general—a testament to its popularity and market dominance.

• Xeomin: Xeomin, while less recognisable to the average consumer, is steadily growing in popularity among injectors and clients who prioritise its pure formulation. It is often described as the “next generation” of botulinum toxin products due to its simplified composition.

4. Clinical Effectiveness: Do the Differences Matter?

When it comes to results, both Botox and Xeomin are highly effective at relaxing dynamic wrinkles caused by repeated muscle movements, such as crow’s feet, frown lines, and forehead creases. Both products start working within days and offer results that typically last 3–4 months, depending on individual factors like metabolism and lifestyle.

However, the choice between the two may come down to patient preference, practitioner experience, or considerations like potential immune responses (in favour of Xeomin) and brand familiarity (favouring Botox).

5. Cost and Availability: Factors to Consider

While pricing varies by clinic and region, Xeomin may sometimes be slightly more cost-effective due to its lack of cold chain requirements, which can reduce logistical expenses. However, Botox’s widespread recognition and established market presence often make it a default choice for many clients.

Which One Is Right for You?

The choice between Botox and Xeomin depends on various factors, including:

• Your Aesthetic Goals: Both deliver smooth, natural-looking results, but your practitioner can guide you on which product aligns best with your specific needs.

• Medical History: If you’ve used botulinum toxin products frequently in the past, Xeomin’s pure formulation may reduce the risk of diminished results over time.

• Practitioner Preference: Some injectors may favour one product over the other based on their handling or specific expertise.

Partner with Experts Who Support Your Practice

At MO by JC, we understand that choosing the right botulinum toxin product—whether Botox or Xeomin—is a crucial decision for aesthetic injectors. With our expert medical oversight services, we provide you with the clinical support, standing orders, and guidance you need to deliver safe, effective treatments tailored to your clients' needs.

Curious about integrating these treatments into your practice? Schedule a virtual meet-and-greet today to explore how partnering with MO by JC can help you grow your skills, expand your treatment offerings, and feel confident in every injection.

📆 Click [here] to book your session—let’s elevate your aesthetics journey together!

Botox®, Prescription Medicine for the treatment of frown lines and crow's feet around the eyes. Botox® has risks and benefits. Ask your doctor if Botox® is right for you. Botulinum toxin type A 50, 100, 200 Units. For product information check with your doctor or Consumer Medicine Information on www.medsafe.govt.nz. Allergan, Auckland.

Xeomin® (incobotulinum toxin) Prescription Medicine for the treatment of upper facial lines: glabellar frown lines, crow's feet round the eyes, horizontal forehead lines. Xeomin® has risks and benefits. Ask your doctor if Xeomin® is right for you (incobotulinum toxin A, purified Botulinum toxin type A 50 Units and 100 Units). For product information check with your doctor or Consumer Medicine Information on www.medsafe.govt.nz. Merz, Sydney. Distributed by Healthcare Logistics, Auckland.